Risk indicators of reduction limb defects.

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Risk indicators of reduction limb defects.

The birth of a child with a reduction limb defect (RLD) was evaluated in relation to vaginal bleeding, threatened abortion, and other complications of pregnancy, placental weight, birth weight, family history, parental age, and the outcome of previous pregnancies. The material consisted of 453 cases of reduction limb defect and an equal number of non-malformed controls matched for time and plac...

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Limb reduction defects text.PDF

Of all congenital anomalies, limb reduction defects maintain a high profile with the public. In the early 1960s, high rates of limb reductions were associated with expectant mothers taking the drug thalidomide. As a result of this, congenital anomaly surveillance systems were established to try and prevent further such episodes. In the late 1980s limb reductions were found to be associated with...

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Congenital scalp defects with distal limb reduction anomalies.

Scalp defects occur as an isolated abnormality or in association with other malformations, and familial cases were first reported by Feud et all in 1945 and Tisserand-Perier2 in 1953. In 1945, Adams and Oliver3 were the first to report the distinct association of scalp defects with distal limb anomalies. Later reports in the mid-1970s by Burton et al4 and Scribanu and Temtamy5 showed that the c...

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Limb reduction defects in endothelial nitric oxide synthase-deficient mice.

Nitric oxide synthases are a family of enzymes capable of converting l-arginine to l-citrulline with the subsequent release of nitric oxide (NO). NO has been shown to have multiple biologic effects depending on the isoform responsible for its production and its tissue of origin. Murine endothelial nitric oxide synthase (eNOS) is encoded by Nos3, located on mouse chromosome 5. NO produced from t...

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Perforator Flaps for Reconstruction of Lower Limb Defects

BACKGROUND Reconstruction of soft tissue defects in the lower third of the leg remains challenging. Anatomical constraints limit the local options available for complex defects especially lower third of leg. Local flaps based on perforator vessels are raising interest in reconstructive surgery of the limbs. We present our experience with perforator flaps for reconstruction of soft tissue def...

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ژورنال

عنوان ژورنال: Journal of Epidemiology & Community Health

سال: 1983

ISSN: 0143-005X

DOI: 10.1136/jech.37.1.50